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ESR 3 – Panagiotis Georgiou

ESR project: Development of Glyco-Nanoparticle Libraries Based on Gold/Polymer Hybrids

Supervisor: Prof Matthew I. Gibson

Institution: University of Warwick, UK

Country of origin: Cyprus

NanoCarb Research: Panagiotis work involves the design and synthesis of well-defined polymers via RAFT-mediated polymerization for glycan conjugation. The project goal to produce a library of simple glycopolymer building blocks that will be subsequently grafted into gold nanoparticle surfaces. The overarching aim of this work will be to fine-tune the glycan composition and polymer type and length to evaluate the nanoparticle behaviour and therapeutic effects.

Publications and other dissemination in NanoCarb:

  1. Panagiotis G. Georgiou, Alexander N. Baker, Sarah-Jane Richards, Antonio Laezza, Marc Walker and Matthew I. Gibson, Tuning aggregative versus non-aggregative lectin binding with glycosylated nanoparticles by the nature of the polymer ligand, Journal of Materials Chemistry B. 2019, Advance Article. Open Access
  2. Panagiotis G. Georgiou, Ioanna Kontopoulou, Thomas R. Congdon and Matthew I. Gibson. Ice recrystallisation inhibiting polymer nano-objects via saline-tolerant polymerisation-induced self-assembly. Materials Horizon. 2020, Advance Article. Open Access.
  3. Alessia Pancaro, Michal Szymonik, Panagiotis G. Georgiou, Alexander N Baker, Marc Walker, Peter Adriaensens, Jelle Hendrix, Matthew I. Gibson, and Inge Neliggen. The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors due to Biocorona Formation. Nanoscale, 2021. Open Access.
  4. Milica Velimirovic, Alessia Pancaro, Robert Mildner, Panagiotis G. Georgiou, Kristof Tirez, Inge Nelissen, Christoph Johann, Matthew I. Gibson, and Frank Vanhaecke. Characterization of Gold Nanorods Conjugated with Synthetic Glycopolymers Using an Analytical Approach Based on spICP-SFMS and EAF4-MALS. Nanomaterials 2021, 11, no. 10: 2720. Open Access.
  5. Panagiotis G. Georgiou, Antonio Laezza, Alexander N. Baker, Sarah-Jane Richards, Ioanna Kontopoulou, Marc Walker, Thomas R. Congdon and Matthew I. Gibson. New Nanomaterial Design Principles for Biomimics. Macro group UK’s Young Researchers Meeting (YRM2020), 29-30 June 2020. Poster.
  6. Alexander N. Baker, Sarah-Jane Richards, Sarojini Pandey, Collette S. Guy, Ashfaq Ahmad, Muhammad Hasan, Caroline I. Biggs, Panagiotis G. Georgiou, Alexander J. Zwetsloot, Anne Straube, Simone Dedola, Robert A. Field, Neil R Anderson, Marc Walker, Dimitris Grammatopoulos, and Matthew I. Gibson. Glycan-Based Flow-Through Device for the Detection of SARS-COV-2. ACS Sens. 2021. Open Access.
  7. Milica Velimirovic, Alessia Pancaro, Robert Mildner, Panagiotis G. Georgiou, Kristof Tirez, Inge Nelissen, Christoph Johann, Matthew I. Gibson, and Frank Vanhaecke. Joint Forces of HR-Spicp-MS and EAF4-MALS for Characterization of Gold Nanorods Conjugated with Synthetic Glycopolymers. Materials Proceedings. 2021. Open Access.
  8. Alexander N. Baker, Thomas R. Congdon, Sarah-Jane Richards, Panagiotis G. Georgiou, Marc Walker, Simone Dedola, Robert A. Field, and Matthew I. Gibson. End-Functionalized Poly(vinylpyrrolidone) for Ligand Display in Lateral Flow Device Test Lines. ACS Polym. Open Access.
  9. Alessia Pancaro, Michal Szymonik, Panagiotis G. Georgiou, Alexander N Baker, Marc Walker, Peter Adriaensens, Jelle Hendrix, Matthew I. Gibson, and Inge Nelissen. The Nature of The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors in Complex Media due to Biocorona Formation. NanoMed Europe ’21 conference, 7-9 September 2021. Poster.
  10. Alexander N. Baker, Asier R. Muguruza, Sarah-Jane Richards, Panagiotis G. Georgiou, Stephen Goetz, Marc Walker, Simone Dedola, Robert A. Field, and Matthew I. Gibson. Lateral Flow Glyco-Assays for the Rapid and Low-Cost Detection of Lectins–Polymeric Linkers and Particle Engineering Are Essential for Selectivity and Performance. Advanced Healthcare Materials. Open Access.
  11. Alessia Pancaro, Michal Szymonik, Panagiotis G. Georgiou, Alexander N Baker, Marc Walker, Peter Adriaensens, Jelle Hendrix, Matthew I. Gibson, and Inge Nelissen. The Nature of The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors in Complex Media due to Biocorona Formation. C’Nano 2020, Toulouse, FR,  23-25 November 2021. Poster.
  12. Panagiotis G. Georgiou, Collette S. Guy, Muhammad Hasan, Ashfaq Ahmad, Sarah-Jane Richards, Alexander N. Baker, Neer V. Thakkar, Marc Walker, Sarojini Pandey, Neil R. Anderson, Dimitris Grammatopoulos, and Matthew I. Gibson. Plasmonic Detection of SARS-CoV‑2 Spike Protein with Polymer-Stabilized Glycosylated Gold Nanorods. ACS Macro Lett. 2022, 11, 317−322. Open Access.
  13. Alexander N. Baker, George W. Hawker-Bond, Panagiotis G. Georgiou, Simone Dedola, Robert A. Field, Matthew I. Gibson. Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow, Chemical Society Reviews, 2022. Open Access.
  14. Toru Ishibe, Natalia Gonzalez-Martinez, Panagiotis G. Georgiou, Kathryn A. Murray, and Matthew I. Gibson. Synthesis of Poly(2-(methylsulfinyl)ethyl methacrylate) via Oxidation of Poly(2-(methylthio)ethyl methacrylate): Evaluation of the Sulfoxide Side Chain on Cryopreservation. ACS Polymers, 2022. Open Access.
  15. Ashfaq Ahmad, Panagiotis G. Georgiou, Alessia Pancaro, Muhammad Hasan, Inge Nelissen, and Matthew I. Gibson. Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding. NanoScale. 2022. Open Access.
  16. Panagiotis G. Georgiou, Nina L. H. Kinney, Ioanna Kontopoulou, Alexander N. Baker, Steven A. Hindmarsh, Akalabya Bissoyi, Thomas R. Congdon, Thomas F. Whale, and Matthew I. Gibson. Poly(vinyl alcohol) Molecular Bottlebrushes Nucleate Ice. Biomacromolecules. 2022. Open Access.
  17. Julian Micallefa, Alexander N. Baker, Sarah-Jane Richards, Douglas E. Soutar, Panagiotis G. Georgiou, Marc Walker and Matthew I. Gibson. Polymer-tethered glyconanoparticle colourimetric biosensors for lectin binding: structural and experimental parameters to ensure a robust output. RSC Adv. 2022. Open Access.
  18. Marta M. P. S. Neves, Sarah-Jane Richards, Alexander N. Baker, Marc Walker, Panagiotis G. Georgiou and Matthew I. Gibson. Discrimination between protein glycoforms using lectin-functionalised gold nanoparticles as signal enhancers. Nanoscale Horizons. 2023. Open Access.
  19. Nicola Judge, Panagiotis G. Georgiou, Akalabya Bissoyi, Ashfaq Ahmad, Andreas Heise and Matthew I. Gibson. High Molecular Weight Polyproline as a Potential Biosourced Ice Growth Inhibitor: Synthesis, Ice Recrystallization Inhibition, and Specific Ice Face Binding. Biomacromolecules. 2023. Open Access.

Scientific Background: Panagiotis holds a B.Sc. degree in Chemistry (with specialisation in Biological Chemistry) from the University of Cyprus. During his final year, he undertook a research project in the area of colloids, investigating the development of protein-based nanoparticles as drug delivery systems. Following his graduation in 2017, he moved to the UK to pursue an M.Sc. (by Research) course in Chemistry at the University of Warwick under the supervision of Prof. Rachel O’Reilly. His work there focused on the preparation of novel nanomaterials by RAFT-mediated polymerization-induced self-assembly (PISA) for bio-related applications.