ESR 11 – Alessia Pancaro

ESR project: Biosensing platform for lectin detection related to cerebrovascular disease using nanoplasmonics

Supervisor: Dr Inge Nelissen

Institution: VITO, BE

Country of origin: Italy

NanoCarb research: Alessia will focus on the development of a nanoplasmonics-based biosensing platform using gold nanorods (GNRs) for the detection of lectin biomarkers in liquid biopsies for early-stage diagnostics of stroke. She will design and characterize GNRs conjugated with glycopolymers, assess glycopolymer-lectin binding properties and optimize of the localized surface plasmon resonance (LSPR)-based method for in vitro diagnostic detection of lectins in human serum samples.

Publications and dissemination material:

  1. Alessia Pancaro, Michal Szymonik, Panagiotis G. Georgiou, Alexander N Baker, Marc Walker, Peter Adriaensens, Jelle Hendrix, Matthew I. Gibson, and Inge Neliggen. The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors due to Biocorona Formation. Nanoscale, 2021. Open Access.
  2. Milica Velimirovic, Alessia Pancaro, Robert Mildner, Panagiotis G. Georgiou, Kristof Tirez, Inge Nelissen, Christoph Johann, Matthew I. Gibson, and Frank Vanhaecke. Characterization of Gold Nanorods Conjugated with Synthetic Glycopolymers Using an Analytical Approach Based on spICP-SFMS and EAF4-MALS. Nanomaterials 2021, 11, no. 10: 2720. Open Access.
  3. Alessia Pancaro, Michal Szymonik, Sarah Deville, Jelle Hendrix and Inge Nelissen. Biosensing platform for lectin detection using nanoplasmonics. DIATECH 2020, Leuven, BE, 27-29 January 2020. Poster
  4. Alessia Pancaro, Michal Szymonik, Panagiotis G. Georgiou, Alexander N Baker, Marc Walker, Peter Adriaensens, Jelle Hendrix, Matthew I. Gibson, and Inge Nelissen. The Nature of The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors in Complex Media due to Biocorona Formation. NanoMed Europe ’21 conference, 7-9 September 2021. Poster.
  5. Alessia Pancaro, Michal Szymonik, Panagiotis G. Georgiou, Alexander N Baker, Marc Walker, Peter Adriaensens, Jelle Hendrix, Matthew I. Gibson, and Inge Nelissen. The Nature of The Polymeric Glyco-Linker Controls the Signal Outputs for Plasmonic Gold Nanorods Biosensors in Complex Media due to Biocorona Formation. C’Nano 2020, Toulouse, FR,  23-25 November 2021. Poster.
  6. Gizem Erol, Patricia Pérez Schmidt, Alessia Pancaro, Javier M. Melo Diaz, Africa G. Barrientos, John Porter, Laura Polito, Michal Szymonik, Inge Nelissen, Daniel I.R. Spencer, Arianna Piotti, Marten Beeg, Maria-Grazia De Simoni, Stefano Fumagalli, Marco Gobbi. New nanostructures inhibiting human mannose binding lectin identified by a novel surface plasmon resonance assay, Sensors and Actuators B: Chemical, Volume 360, 2022, 131661. Open Access.
  7. Ashfaq Ahmad, Panagiotis G. Georgiou, Alessia Pancaro, Muhammad Hasan, Inge Nelissen, and Matthew I. Gibson. Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding. NanoScale. 2022. Open Access.

Scientific background: Alessia obtained a M.Sc in Molecular and Industrial biotechnology and a Bachelor’s degree in Biomolecular and Industrial biotechnology at the Università degli Studi di Napoli Federico II.