ESR project: In vivo fate studies of glyco NPs and biocorona stability.
Supervisor: Dr Jordi Llop
Institution: CIC biomaGUNE, ES
Country of origin: Italy
NanoCarb research: Gold nanoparticles with different sizes and shapes will be synthetized and decorated at the surface with thiol-functionalised carbohydrates. Radiolabelling strategies for the incorporation of positron emitters both at the core and the shell of the NPs will be developed and applied. The biodistribution and biological fate of novel nanosystems will be first investigated in healthy rodents using Positron Emission Tomography (PET) in combination with other imaging modalities. Finally, selected NPs will be investigated as imaging probes in mouse and rat models of cerebral ischemia. In parallel, the labelling strategies developed within the project will be applied to NPs provided by other partners in order to investigate biodistribution, fate and biocorona stability.
Publications and dissemination material:
- Riccardo Rovina (ESR 14), Jordi Llop, Monica Carril, Preparation of gold glyconanoparticles (AuGNPs) as theragnostic agents for brain ischemia, The 3rd Biennial Young Researchers Workshop on Biomaterials and Applications (bioMAPP19), 4 December 2019. Poster
Scientific background: During his Bachelor studies, Riccardo studied the selective idrogenation of glycerol to 1,2-propanediol under the supervision of Paolo Centomo in the University of Padova (Italy). He spent one month in a microbiology laboratory for an internship, and passed the State Exam for Chemistry. He obtained his Master Degree in Chemistry at the University of Padova (Italy) in 2017, in the Surface Science Group under the supervision of Stefano Agnoli. The Master thesis was about the growth of a MOF’s thin layer upon different titanium dioxide substrates, using an innovative technique called Layer-by-Layer that allow controlling the thickness of the layer and the texture of the MOF’s lattice.